All-trans retinoic acid regulates hepatic bile acid homeostasis

All-trans-retinoic acid: measurement

A quantitative determination of physiological levels of all-trans-retinoic acid (vitamin A acid) in human serum has been developed. A double-phase extraction of 3.5 ml of serum followed by a specific and sensitive high performance liquid chromatography procedure allowed measurement of levels down to 1 ng/ml. Serum concentrations in 37 fasting volunteers ranged from 2.7 to 4.2 ng/ml and fitted a...

All-trans Retinoic Acid Regulates the Balance of Treg-Th17 Cells through ERK and P38 Signaling Pathway

All-trans-retinoic acid and bleeding/thrombosis.

Hematology-Oncology Department Ospedali Riuniti Largo Barozzi, 1 24128 Bergamo (Italy) Tel. 39 035 269492, Fax 39 035 266659 E-Mail [email protected] All-trans-retinoic acid (ATRA) inhibits cell growth and proliferation by inducing cyto-differentiation and/or apoptosis in several cell types. These effects have become a therapeutic objective in human cancers. In addition to these functions, ...

All Trans Retinoic Acid (ATRA) induced myositis.

A 5-year-old girl presented with fever, skin and mucosal bleeds, and pallor. Her hemoglobin was 3.6 g/dL, total white cell count 4.5×103/μL and platelet count 13×103/μL. Peripheral smear revealed 30% blasts, confirmed as APML on bone marrow examination. Cytogenetic analysis showed the typical translocation of t(15:17) with 77% of interphase cells expressing PML:RARA gene fusion. Child was start...

Metabolites of all-trans-retinoic acid in bile: identification of all-trans- and 13-cis-retinoyl glucuronides.

The metabolites of all-trans-[3H]retinoic acid were studied in the rat bile. In the bile duct cannulated rat 80 to 86% of the dose is excreted into the bile within 24 h after the intravenous administration of either a physiological or pharmacological dose of all-trans-[3H]retinoic acid. Polar metabolites of retinoic acid predominate (73 to 96% of bile 3H) in the bile at all times; some free ret...